I can tell you I've never used a better joint supplement than this and I've tried them all. I was told a few years ago I need a knee replacement. I tried a couple of cortisone shots. The first helped the second did nothing. I've always been very active. A lot of different exercises over the years and a physical job. I know this works great because I got lazy and didn't take it for a month and my knee was in pain again. I started taking it again and by the fifth day it was already working.