Thyrogard Ingredient Research

L-Tyrosine

L-Tyrosine

"Tyrosine use in summer was associated with no change in mood and a 30% decline in TSH, while in winter there was a 47% improvement in mood and TSH decreased by 28%. [...] Administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo."

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Palinkas LA, Reedy KR, Smith M, Anghel M, Steel GD, Reeves D, Shurtleff D, Case HS, Van Do N, Reed HL. Int J Circumpolar Health. 2007 Dec;66(5):401-17.

Zhihua W, Jinghua L, Zhiming W, Lingyan X, Yi Z, Yingjie C, Jun S, and Zhongming L.

Neural Regen Res. 2012 Jun 25; 7(18): 1413–1419.

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Sarne D.

Endotext. 2016 Sep 27.

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Green WL.

J Clin Invest. 1971 Dec; 50(12): 2474–2484.

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Kostoglou-Athanassiou I, Ntalles K.

Hippokratia. 2010 Apr-Jun; 14(2): 82–87.

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Khaliq W, Andreis DT, Kleyman A, Gräler M, and Singer M.

Intensive Care Med Exp. 2015 Dec; 3(Suppl 1): A686.

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Bladderwrack

Bladderwrack

"Seaweed ingestion increased I/C concentrations [...] and serum TSH. [...] Seven weeks of [...] seaweed supplementation was associated with a small but statistically significant increase in TSH."

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BTeas J, Braverman LE, Kurzer MS, Pino S, Hurley TG, Hebert JR. J Med Food. 2007 Mar;10(1):90-100.

Zava TT, Zava DT.

Thyroid Res. 2011; 4: 14.

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Catarino MD, Silva AMS, Cardoso SM.

Mar Drugs. 2018 Aug; 16(8): 249.

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Aquaron R, Delange F, Marchal P, Lognoné V, Ninane L.

Cell Mol Biol (Noisy-le-grand). 2002 Jul;48(5):563-9.

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Shokri Z, Khoshbin M, Koohpayeh A, Abbasi N, Bahmani F, Rafieian-Kopaei M, Beyranvand F.

International Journal of Green Pharmacy. July-Sep 2018 (Suppl). 12 (3) | S474.

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Kelp

Kelp

"In the present study, we tested a commercially available encapsulated edible [kelp] for its acceptability to consumers and iodine bioavailability and investigated the impact of a 2-week daily seaweed supplementation on iodine concentrations and thyroid function. [...] The concentrations of thyroid-stimulating hormone increased. [...] The seaweed was palatable and acceptable to consumers as a whole food or as a food ingredient and effective as a source of iodine in an iodine-insufficient population."

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Combet E, Ma ZF, Cousins F, Thompson B, Lean ME. Br J Nutr. 2014 Sep 14;112(5):753-61. doi: 10.1017/S0007114514001573. Epub 2014 Jul 9.

Takeuchi T, Kamasaki H, Hotsubo T, Tsutsumi H.

Clin Pediatr Endocrinol. 2011 Jul; 20(3): 51–55.

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Clark CD, Bassett B, Burge MR.

Endocr Pract. 2003 Sep-Oct;9(5):363-9.

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Key TJ, Thorogood M, Keenan J, Long A.

Journal of Human Nutrition and Dietetics, 5: 323-326.

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Turmeric

Turmeric

"Curcumin is a potent antioxidant that works through several mechanisms. The aim of the present study was to demonstrate the hormonal, histological, and ultrastructural changes occurred in the thyroid gland [...] and study the possible protective effect of curcumin on [these] effects. [...] [The study found that] curcumin was protective against toxic effects [to the thyroid gland]."

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Abdelaleem MM, El-Tahawy NFG, Abozaid SMM, Abdel-Hakim SA. Endocr Regul. 2018 Apr 1;52(2):59-68. doi: 10.2478/enr-2018-0007.

Jawa A, Jawad A, Riaz SH, Assir MZ, Chaudhary AW, Zakria M, Akram J.

Indian J Endocrinol Metab. 2015 May-Jun;19(3):347-50. doi: 10.4103/2230-8210.152768.

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Deshpande UR, Joseph LJ, Patwardhan UN, Samuel AM.

Indian J Exp Biol. 2002 Jun;40(6):735-8.

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Mishra P, Paital B, Jena S, Swain SS, Kumar S, Yadav MK, Chainy GBN, Samanta L.

Sci Rep. 2019 May 15;9(1):7408. doi: 10.1038/s41598-019-43320-5.

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Papiez MA, Kaja M, Gebarowska A.

Folia Histochem Cytobiol. 2008;46(2):205-11. doi: 10.2478/v10042-008-0031-6.

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Bioperine

Bioperine®

"Piperine supplementation [...] improved the plasma levels of [T3 and T4], and significantly reduced [TSH] to near normal levels. [...] The data presented here provide evidence that piperine possesses thyrogenic activity."

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Vijayakumar RS, Nalini N. J Basic Clin Physiol Pharmacol. 2006;17(2):71-86.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS.

Planta Med. 1998 May;64(4):353-6.

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Jäger R, Lowery RP, Calvanese AV, Joy JM, Purpura M, Wilson JM.

Nutr J. 2014; 13: 11.

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Hewlings SJ, Kalman DS.

Foods. 2017 Oct 22;6(10). pii: E92. doi: 10.3390/foods6100092.

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Hewlings SJ, Kalman DS.

Foods. 2017 Oct; 6(10): 92.

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Prasad S, Tyagi KA, Aggarwal BB.

Cancer Res Treat. 2014 Jan; 46(1): 2–18.

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