Ingredient Research
UC-II® Collagen
"After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo. [...] The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90. [...] It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120. [...] No product related adverse events were observed during the study."
Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP.
Int J Med Sci. 2009 Oct 9;6(6):312-21.
Lerman RH Chang JL Konda V Desai A Montalto MB.
Integr Med (Encinitas). 2015 Oct;14(5):52-61.
Bagi CM, Berryman ER, Teo S, Lane NE.
Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090. doi: 10.1016/j.joca.2017.08.013. Epub 2017 Sep 6.
Toxicol Mech Methods. 2007;17(4):189-96. doi: 10.1080/15376510600910469.
D'Altilio M, Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad JT, Bagchi M, Bagchi D.
Deparle LA, Gupta RC, Canerdy TD, Goad JT, D'Altilio M, Bagchi M, Bagchi D.
J Vet Pharmacol Ther. 2005 Aug;28(4):385-90.
Boswellia Serrata
"Clinical efficacy was evaluated every fortnight on the basis of severity of pain, morning stiffness, Ritchie articular index, joint score, disability score and grip strength. Other parameters like erythrocyte sedimentation rate and radiological examination were carried out on a monthly basis. Treatment with the herbomineral formulation produced a significant drop in severity of pain (P less than 0.001) and disability score (P less than 0.05)"
Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SP.
Arthritis Res Ther. 2008;10(4):R85. doi: 10.1186/ar2461. Epub 2008 Jul 30.
Vishal AA, Mishra A, Raychaudhuri SP.
Int J Med Sci. 2011;8(7):615-22. Epub 2011 Oct 12.
Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, Raychaudhuri SK, Raychaudhuri SP.
Int J Med Sci. 2010 Nov 1;7(6):366-77.
Gupta PK, Samarakoon SM, Chandola HM, Ravishankar B.
Ayu. 2011 Oct;32(4):478-82. doi: 10.4103/0974-8520.96119.
MSM
"A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee OA pain were enrolled in an outpatient medical center. [...] Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). [...] MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation (P<0.05)."
van der Merwe M, Bloomer RJ.
J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. Epub 2016 Oct 23.
Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B.
Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6. doi: 10.1177/0394632015622215. Epub 2015 Dec 18.
Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B.
Acta Med Indones. 2017 Apr;49(2):105-111.
Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.
BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50.
Turmeric
"Over all significant improvement was observed in the patients of [turmeric] extract group as compared to placebo group. [...] It may be concluded that on chronic administration, [turmeric] suppresses inflammation and brings clinical improvement in patients of [osteoarthritis of the knee], which may be observed by decreased level of IL-1β and VAS/WOMAC scores, respectively. At the same time, [turmeric] decreases the oxidative stress also."
Inflammation. 2011 Aug;34(4):291-301. doi: 10.1007/s10753-010-9278-0.
Ramadan G, Al-Kahtani MA, El-Sayed WM.
Madhu K, Chanda K, Saji MJ.
Inflammopharmacology. 2013 Apr;21(2):129-36. doi: 10.1007/s10787-012-0163-3. Epub 2012 Dec 16.
Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V.
J Altern Complement Med. 2009 Aug;15(8):891-7. doi: 10.1089/acm.2008.0186.
Park S, Lee LR, Seo JH, Kang S.
Genes Nutr. 2016 Mar 17;11:2. doi: 10.1186/s12263-016-0520-4. eCollection 2016.
Bioperine®
"Piperine significantly reduced nociceptive and arthritic symptoms at days 8 and 4, respectively. Histological staining showed that piperine significantly reduced the inflammatory area in the ankle joints. [...] These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects."
Ying X, Chen X, Cheng S, Shen Y, Peng L, Xu HZ.
Int Immunopharmacol. 2013 Oct;17(2):293-9. doi: 10.1016/j.intimp.2013.06.025. Epub 2013 Jul 6.
Mujumdar AM, Dhuley JN, Deshmukh VK, Raman PH, Naik SR.
Jpn J Med Sci Biol. 1990 Jun;43(3):95-100.
Umar S, Golam Sarwar AH, Umar K, Ahmad N, Sajad M, Ahmad S, Katiyar CK, Khan HA.
Cell Immunol. 2013 Jul-Aug;284(1-2):51-9. doi: 10.1016/j.cellimm.2013.07.004. Epub 2013 Jul 19.
Tasleem F, Azhar I, Ali SN, Perveen S, Mahmood ZA.
Asian Pac J Trop Med. 2014 Sep;7S1:S461-8. doi: 10.1016/S1995-7645(14)60275-3.