Prostacor Ingredient Research

Saw Palmetto

Saw Palmetto

"The [prostate] inflammatory hypothesis was tested in humans. Our pilot study shows a significant reduction of some inflammatory parameters in prostatic tissues of patients treated with [saw palmetto]. These biological findings justify a pharmacological effect [...] on the inflammatory status of the adenoma. A correlation with clinical improvement was observed."

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Vela Navarrete R, Garcia Cardoso JV, Barat A, Manzarbeitia F, López Farré A. Eur Urol. 2003 Nov;44(5):549-55.

Paubert-Braquet M, Mencia Huerta JM, Cousse H, Braquet P.

Prostaglandins Leukot Essent Fatty Acids. 1997 Sep;57(3):299-304.

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Breu W, Hagenlocher M, Redl K, Tittel G, Stadler F, Wagner H.

Arzneimittelforschung. 1992 Apr;42(4):547-51.

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Iehlé C, Délos S, Guirou O, Tate R, Raynaud JP, Martin PM.

J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):273-9.

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Weisser H, Tunn S, Behnke B, Krieg M.

Prostate. 1996 May;28(5):300-6.

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Palin MF, Faguy M, LeHoux JG, Pelletier G.

Endocrine. 1998 Aug;9(1):65-9.

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Beta-Sitosterol

Beta-Sitosterol

"38 patients who continued beta-sitosterol treatment had stable values for all outcome variables between the end of the double-blind study and after 18 months of follow-up. The 41 patients choosing no further therapy had slightly worse symptom scores and PVR, but no changes in Qmax. Of the former placebo group, 27 patients who started beta-sitosterol after the double-blind trial improved to the same extent as the treated group for all outcome variables. The 18 patients choosing no further therapy showed no signs of improvement."

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Berges RR, Kassen A, Senge T. BJU Int. 2000 May;85(7):842-6.

Wilt T, Ishani A, MacDonald R, Stark G, Mulrow C, Lau J.

Cochrane Database Syst Rev. 2000;(2):CD001043.

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Berges RR, Windeler J, Trampisch HJ, Senge T.

Lancet. 1995 Jun 17;345(8964):1529-32.

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Klippel KF, Hiltl DM, Schipp B.

Br J Urol. 1997 Sep;80(3):427-32.

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Wilt TJ, MacDonald R, Ishani A.

BJU Int. 1999 Jun;83(9):976-83.

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Stinging Nettle

Stinging Nettle

"One group was given nettle and other group placebo [...] similarly and consistently for a period of 8 weeks. [...] No side effects were reported by the patients in the end of the study. According to the results, nettle had a better effect in relieving clinical symptoms in [...] patients compared to placebo."

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Ghorbanibirgani A, Khalili A, Zamani L. Iran Red Crescent Med J. 2013 Jan;15(1):9-10. doi: 10.5812/ircmj.2386. Epub 2013 Jan 5.

Nahata A, Dixit VK.

Andrologia. 2012 May;44 Suppl 1:396-409. doi: 10.1111/j.1439-0272.2011.01197.x. Epub 2011 Aug 2.

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Hirano T, Homma M, Oka K.

Planta Med. 1994 Feb;60(1):30-3.

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Schneider T, Rübben H.

Urologe A. 2004 Mar;43(3):302-6.

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Safarinejad MR.

J Herb Pharmacother. 2005;5(4):1-11.

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Pumpkin Seed

Pumpkin Seed

"A total of 1,431 men (50-80 years) with [enlarged prostates] were randomly assigned to either pumpkin seed, [...] capsules with pumpkin seed extract [...] or matching placebo. [...] In the case of pumpkin seed [...], the difference compared with placebo [...] was descriptively significant. The study products were well tolerated. Overall, [...] 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS [(International Prostate Symptom Score)] compared with placebo."

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Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Urol Int. 2015;94(3):286-95. doi: 10.1159/000362903. Epub 2014 Sep 5.

Gossell-Williams M, Davis A, O'Connor N.

J Med Food. 2006 Summer;9(2):284-6.

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Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA, deKernion JB.

J Urol. 2000 May;163(5):1451-6.

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Tsai YS, Tong YC, Cheng JT, Lee CH, Yang FS, Lee HY.

Urol Int. 2006;77(3):269-74.

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Carbin BE, Larsson B, Lindahl O.

Br J Urol. 1990 Dec;66(6):639-41.

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Lycopene

Lycopene

"The results show that lycopene significantly inhibited the growth of [normal human prostate epithelial cells] in a dose-dependent fashion. Flow cytometry revealed a significant cell cycle arrest in the G0/G1 phase. This effect was confirmed by inhibition of cyclin D1 protein expression, whereas cyclin E levels remained unchanged. The results demonstrate that lycopene inhibits growth of nonneoplastic [normal human prostate epithelial cells] in vitro. [...] This might have an effect on prostate development and/or on enlargement of prostate tissue."

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Obermüller-Jevic UC, Olano-Martin E, Corbacho AM, Eiserich JP, van der Vliet A, Valacchi G, Cross CE, Packer L. J Nutr. 2003 Nov;133(11):3356-60.

Schwarz S1, Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK.

J Nutr. 2008 Jan;138(1):49-53.

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Wertz K.

Nutr Cancer. 2009;61(6):775-83. doi: 10.1080/01635580903285023.

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Zou Y, Aboshora W, Li J, Xiao T, Zhang L.

Phytother Res. 2017 Aug;31(8):1192-1198. doi: 10.1002/ptr.5838. Epub 2017 Jun 20.

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Minutoli L, Bitto A, Squadrito F, Marini H, Irrera N, Morgia G, Passantino A, Altavilla D.

Curr Med Chem. 2013;20(10):1306-12.

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Wertz K, Siler U, Goralczyk R.

Arch Biochem Biophys. 2004 Oct 1;430(1):127-34.

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