Ingredient Research
Benfotiamine
Benfotiamine
A statistically significant [...] improvement [...] was observed in the group given [benfotiamine] when compared to the placebo-treated controls. [...] The most pronounced effect on complaints was a decrease in pain [...] More patients in the benfotiamine-treated group than in the placebo group considered their clinical condition to have improved.
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Winkler G, Pál B, Nagybéganyi E, Ory I, Porochnavec M, Kempler P. Arzneimittelforschung. 1999 Mar;49(3):220-4.
Read the AbstractWu S, Ren J. Neurosci Lett. 2006 Feb 13;394(2):158-62.
Read the AbstractWoelk H, Lehrl S, Bitsch R, Köpcke W. Alcohol Alcohol. 1998 Nov-Dec;33(6):631-8.
Read the AbstractSánchez-Ramírez GM, Caram-Salas NL, Rocha-González HI, Vidal-Cantú GC, Medina-Santillán R, Reyes-García G, Granados-Soto V. Eur J Pharmacol. 2006 Jan 13;530(1-2):48-53.
Read the AbstractStracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5.
Read the AbstractStracke H, Lindemann A, Federlin K. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.
Read the AbstractStirban A, Negrean M, Stratmann B, Gawlowski T, Horstmann T, Götting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D. Diabetes Care. 2006 Sep;29(9):2064-71.
Read the AbstractAlpha Lipoic Acid
Alpha Lipoic Acid
The total symptom score (TSS) (pain, burning, paresthesia, and numbness) in the feet decreased significantly [...] in [the alpha lipoic acid group] vs. [placebo]. Each of the four individual symptom scores was significantly lower in [the alpha lipoic acid group] than in [the placebo group].
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Ziegler D, Ametov A, Barinov A, Dyck PJ, Gurieva I, Low PA, Munzel U, Yakhno N, Raz I, Novosadova M, Maus J, Samigullin R. Diabetes Care. 2006 Nov;29(11):2365-70.
Read the AbstractZiegler D, Reljanovic M, Mehnert H, Gries FA. Exp Clin Endocrinol Diabetes. 1999;107(7):421-30.
Read the AbstractAgathos E, Tentolouris A, Eleftheriadou I, Katsaouni P, Nemtzas I, Petrou A, Papanikolaou C, Tentolouris N. J Int Med Res. 2018 May;46(5):1779-1790.
Read the AbstractPingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. Cureus. 2024 Sep;16(9):e70299.
Read the AbstractDong D, Sun Y, Sui Q, Zhao Z, Ma H, Li K, Yu X. Inflammopharmacology. 2026 Mar;34(3):1973-1990.
Read the AbstractAldendail CF, Chen P, Dibble HS, Baute Penry V. Integr Med (Encinitas). 2024 Jul;23(3):32-39.
Read the AbstractAcetyl L-Carnitine
Acetyl L-Carnitine
Data showed significant improvements in sural nerve fiber numbers and regenerating nerve fiber clusters. [V]ibration perception improved in both studies. Pain as the most bothersome symptom showed significant improvement in one study and in the combined cohort.
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Chiechio S, Copani A, Gereau RW 4th, Nicoletti F. CNS Drugs. 2007;21 Suppl 1:31-8; discussion 45-6.
Read the AbstractDe Grandis D, Minardi C. Drugs R D. 2002;3(4):223-31.
Read the AbstractDi Cesare Mannelli L, Ghelardini C, Calvani M, Nicolai R, Mosconi L, Toscano A, Pacini A, Bartolini A. J Neurosci Res. 2009 Jan;87(1):200-7.
Read the AbstractTraina G. Front Biosci (Landmark Ed). 2016 Jun 1;21(7):1314-29.
Read the AbstractLowitt S, Malone JI, Salem AF, Korthals J, Benford S. Metabolism. 1995 May;44(5):677-80.
Read the AbstractTomassoni D, Di Cesare Mannelli L, Bramanti V, Ghelardini C, Amenta F, Pacini A. Neural Regen Res. 2018 Apr;13(4):692-698.
Read the AbstractBiotin
Biotin
Following the oral administration of biotin [...] from the first day after the surgery until day 21, mechanical allodynia [...] and heat hyperalgesia [...] significantly relieved.
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Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biomed Pharmacother. 1990;44(10):511-4.
Read the AbstractYatzidis H, Koutsicos D, Agroyannis B, Papastephanidis C, Francos-Plemenos M, Delatola Z. Nephron. 1984;36(3):183-6.
Read the AbstractCréange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. BMC Neurol. 2023 Oct 30;23(1):389.
Read the AbstractSedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, Gout O, Lyon-Caen O, Tourbah A. Mult Scler Relat Disord. 2015 Mar;4(2):159-69.
Read the AbstractCervantes A, Daley SF. Biotin Deficiency. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Sep 14.
Read the AbstractFolate
Folate
[Folate] improved the recovery of peripheral nerve injury, which was probably associated with increased Schwann cell proliferation, migration and secretion of NGF. Moreover, we demonstrated that [folate] plays a dose-dependent role in promoting functions of Schwann cells.
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Alves Maues AC, Moren Abat MG, Benlloch M, Mariscal G. Nutrients. 2025 Oct 20;17(20):3299.
Read the AbstractChakraborty J, Ghosh A, Awuah EB, Stabler SP, Field MS, Bailey RL, Stover PJ. Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2528095123.
Read the AbstractChristofides EA, Valentine V. Endocr Pract. 2023 Aug;29(8):663-669.
Read the AbstractKang W, Zhang Y, Cui W, Meng H, Zhang D. Neuromolecular Med. 2025 Mar 31;27(1):23.
Read the AbstractKoike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G. Neurology. 2015 Mar 10;84(10):1026-33.
Read the AbstractKoike H, Hama T, Kawagashira Y, Hashimoto R, Tomita M, Iijima M, Sobue G. Nutrition. 2012 Jul;28(7-8):821-4.
Read the AbstractVitamin B12
Vitamin B12
The treatment of patients with [nerve discomfort] with [...] oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and [quality of life].
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Mansour A, Amrollahi Bioky A, Gerami H, Khorasanian AS, Esmaeili AH, Fateh HR, Aghaei Meybodi HR, Mohajeri-Tehrani MR, Safyari R, Adibi H, Sajjadi-Jazi SM. J Nutr. 2026 Mar;156(3):101368.
Read the AbstractMizukami H, Ogasawara S, Yamagishi S, Takahashi K, Yagihashi S. Eur J Clin Invest. 2011 Apr;41(4):442-50.
Read the AbstractKaredath J, Batool S, Arshad A, Khalique S, Raja S, Lal B, Anirudh Chunchu V, Hirani S. Cureus. 2022 Nov;14(11):e31783.
Read the AbstractRamadhani A, Astuti I, Widiastuti MG, Purwanti N. Korean J Pain. 2024 Oct 1;37(4):299-309.
Read the AbstractWatanabe T, Kaji R, Oka N, Bara W, Kimura J. J Neurol Sci. 1994 Apr;122(2):140-3.
Read the AbstractStein J, Geisel J, Obeid R. Eur J Neurol. 2021 Jun;28(6):2054-2064.
Read the AbstractChromium
Chromium
Chromium [...] administration on the other hand was found to have beneficial effect in normalizing glucose levels, lipid peroxidation and antioxidant status.
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Imanparast F, Mashayekhi FJ, Kamankesh F, Paknejad M, Mobarra N, Faramarzi MA. J Trace Elem Med Biol. 2020 Dec;62:126639.
Read the AbstractAlkhalidi F. J Med Life. 2023 Aug;16(8):1178-1182.
Read the AbstractNayyar H, Bhatti A, John P, Khan G. PeerJ. 2026;14:e20184.
Read the AbstractAlbarracin CA, Fuqua BC, Evans JL, Goldfine ID. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.
Read the AbstractHua Y, Clark S, Ren J, Sreejayan N. J Nutr Biochem. 2012 Apr;23(4):313-9.
Read the AbstractAsbaghi O, Naeini F, Rezaei Kelishadi M, Ghaedi E, Eslampour E, Nazarian B, Ashtary-Larky D, Naeini AA. Pharmacol Res. 2020 Nov;161:105098.
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