Hepagard Ingredient Research

Milk Thistle

Milk Thistle

"Milk thistle extract administration induced a decreasing trend in [non-alcoholic fatty liver disease activity score] compared with the vehicle group. Milk thistle induced a numerical decrease of the steatosis score compared with vehicle, and this was accompanied by a statistically significant decrease in liver weight and the liver-to-body weight ratio."

Read the Abstract

Pais P, D'Amato M. Drugs R D. 2014 Dec;14(4):291-9. doi: 10.1007/s40268-014-0068-2.

Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F.

World J Hepatol. 2013 Mar 27; 5(3): 109–113.

Read the Abstract


Zhong S, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu J.

Medicine (Baltimore). 2017 Dec; 96(49): e9061.

Read the Abstract


Zhu SY, Jiang N, Yang J, Tu J, Zhou Y, Xiao X, Dong Y.

Biomed Pharmacother. 2018 Apr;100:191-197. doi: 10.1016/j.biopha.2018.01.144. Epub 2018 Feb 8.

Read the Abstract


Milosević N, Milanović M, Abenavoli L, Milić N.

Rev Recent Clin Trials. 2014;9(3):195-203.

Read the Abstract


Carmela C, Luigi B, and Ludovico A.

World J Gastroenterol. 2017 Dec 21; 23(47): 8437–8438.

Read the Abstract


N-Acetyl Cysteine

N-Acetyl Cysteine

"Dietary [N-Acetyl Cysteine] is an effective hepatic antioxidant that abolished NASH-induced lipid peroxidation, attenuated reductions in hepatic GSH, blocked NASH-associated autoimmune responses, inhibited the production of TNF-α and attenuated inflammation, leading to significant reduction in cellular damage, hepatocyte injury and fibrosis."

Read the Abstract

Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJJ. J Nutr. 2008 Oct; 138(10): 1872–1879.

Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, Kiani J, Zaare M, Najafipoor F.

Hepat Mon. 2010 Winter;10(1):12-6. Epub 2010 Mar 1.

Read the Abstract


El-Lakkany NH, El-Din SHS, Sabra AA, Hammam OA, Ebeid FA.

Res Pharm Sci. 2016 Oct; 11(5): 374–382.

Read the Abstract


Ali MH, Messiha BA, Abdel-Latif HA.

Pharm Biol. 2016 Jul;54(7):1198-208. doi: 10.3109/13880209.2015.1060247. Epub 2015 Jul 1.

Read the Abstract


Oliveira CP, Cotrim HP, Stefano JT, Siqueira ACG, Salgado ALA, Parise ER.

Arq Gastroenterol. 2019 Aug 13;56(2):184-190. doi: 10.1590/S0004-2803.201900000-36.

Read the Abstract


De Andrade KQ, Moura FA, Dos Santos JM, de Araújo ORP, Santos JCF, Goulart MOF.

Int J Mol Sci. 2015 Dec; 16(12): 30269–30308.

Read the Abstract


Dandelion Root

Dandelion Root

"[Dandelion] significantly increased activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) in liver and muscle protein. [Dandelion] significantly suppressed lipid accumulation in the liver, reduced [metabolic hormone] resistance, and lipid in HFD-fed C57BL/6 mice via the AMPK pathway."

Read the Abstract

Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MJ, Kwon DY, Sung MJ. Food Chem Toxicol. 2013 Aug;58:30-6. doi: 10.1016/j.fct.2013.04.023. Epub 2013 Apr 18.

Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MS, Kim MJ, Kwon DY, Sung MJ.

J Med Food. 2013 Jan;16(1):26-33. doi: 10.1089/jmf.2012.2226. Epub 2012 Dec 20.

Read the Abstract


Hfaiedh M, Brahmi D, Zourgui L.

Environ Toxicol. 2016 Mar;31(3):339-49. doi: 10.1002/tox.22048. Epub 2014 Oct 1.

Read the Abstract


Domitrović R, Jakovac H, Romić Z, Rahelić D, Tadić Z.

J Ethnopharmacol. 2010 Aug 9;130(3):569-77. doi: 10.1016/j.jep.2010.05.046. Epub 2010 Jun 2.

Read the Abstract


Wirngo FE, Lambert MN, Jeppesen PB.

Rev Diabet Stud. 2016 Summer-Fall; 13(2-3): 113–131.

Read the Abstract


Choi UK, Lee OH, Yim JH, Cho CW, Rhee YK, Lim SI, Kim YC.

Int J Mol Sci. 2010 Jan; 11(1): 67–78.

Read the Abstract


Artichoke Leaf

Artichoke Leaf

"Doppler sonography showed increased hepatic vein flow[...], reduced portal vein diameter [...], and liver size [...], reduction in serum ALT [...] and AST [...] levels, improvement in AST/ALT ratio and APRI scores [...], and reduction in total bilirubin. [Artichoke leaf] supplementation reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations."

Read the Abstract

Panahi Y, Kianpour P, Mohtashami R, Atkin SL, Butler AE, Jafari R, Badeli R, Sahebkar A. Phytother Res. 2018 Jul;32(7):1382-1387. doi: 10.1002/ptr.6073. Epub 2018 Mar 9.

Tang X, Wei R, Deng A, Lei T.

Nutrients. 2017 Sep; 9(9): 1000.

Read the Abstract


Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A.

Int J Hepatol. 2016; 2016: 4030476.

Read the Abstract


Ahmadi A, Heidarian E, Ghatreh-Samani K.

J Basic Clin Physiol Pharmacol. 2019 Aug 30;30(5). pii: /j/jbcpp.2019.30.issue-5/jbcpp-2018-0180/jbcpp-2018-0180.xml. doi: 10.1515/jbcpp-2018-0180.

Read the Abstract


Kurt H, Toprak O, Bülbül E.

Case Reports Hepatol. 2014; 2014: 697359.

Read the Abstract


Choline Bitartrate

Choline Bitartrate

"[Subjects] were divided into two groups and fed a [choline deficient] diet with or without 0.2% choline bitartrate for one or three weeks. [...] The [choline deficient] diet lowered liver choline metabolites after one week and exacerbated fatty liver between one and three weeks. We identified >300 genes whose expression was significantly altered in the livers of mice after consumption of this CD diet for one week."

Read the Abstract

Mitsumoto K, Watanabe R, Nakao K, Yonenaka H, Hashimoto T, Kato N, Kumrungsee T, Yanaka N. Life Sci. 2017 Sep 1;184:103-111. doi: 10.1016/j.lfs.2017.07.009. Epub 2017 Jul 12.

Sherriff JL, O'Sullivan TA, Properzi C, Oddo JL, Adams LA.

Adv Nutr. 2016 Jan; 7(1): 5–13.

Read the Abstract


Corbin KD, Zeisel SH.

Curr Opin Gastroenterol. 2012 Mar; 28(2): 159–165.

Read the Abstract


Mehedint MG, Zeisel SH.

Curr Opin Clin Nutr Metab Care. 2013 May; 16(3): 339–345.

Read the Abstract


Wiedeman AM, Barr SI, Green TJ, Xu Z, Innis SM, Kitts DD.

Nutrients. 2018 Oct; 10(10): 1513.

Read the Abstract


Schugar RC, Huang X, Moll AR, Brunt EM, Crawford PA.

PLoS One. 2013; 8(8): e74806.

Read the Abstract


Heo G, Suk K.

Prev Nutr Food Sci. 2019 Mar; 24(1): 32–40.

Read the Abstract