Name: Hepaclear (30 Day Supply)
Brand: Nutreance

Milk Thistle

Milk thistle extract administration induced a decreasing trend in [non-alcoholic fatty liver disease activity score] compared with the vehicle group. Milk thistle induced a numerical decrease of the steatosis score compared with vehicle, and this was accompanied by a statistically significant decrease in liver weight and the liver-to-body weight ratio.
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Pais P, D'Amato M. Drugs R D. 2014 Dec;14(4):291-9. doi: 10.1007/s40268-014-0068-2.

Cacciapuoti F, Scognamiglio A, Palumbo R, Forte R, Cacciapuoti F. World J Hepatol. 2013 Mar 27; 5(3): 109–113.

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Zhong S, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu J. Medicine (Baltimore). 2017 Dec; 96(49): e9061.

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Zhu SY, Jiang N, Yang J, Tu J, Zhou Y, Xiao X, Dong Y. Biomed Pharmacother. 2018 Apr;100:191-197. doi: 10.1016/j.biopha.2018.01.144. Epub 2018 Feb 8.

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Milosević N, Milanović M, Abenavoli L, Milić N. Rev Recent Clin Trials. 2014;9(3):195-203.

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Carmela C, Luigi B, and Ludovico A. World J Gastroenterol. 2017 Dec 21; 23(47): 8437–8438.

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Hesperidin

Hesperidin supplementation, compared with placebo, was associated with a significant reduction in [...] hepatic steatosis. [...] Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD [through] improving lipid profile.
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Cheraghpour M, Imani H, Ommi S, Alavian SM, Karimi-Shahrbabak E, Hedayati M, Yari Z, Hekmatdoost A. Phytother Res. 2019 Aug;33(8):2118-2125.

Wang X, Hasegawa J, Kitamura Y, Wang Z, Matsuda A, Shinoda W, Miura N, Kimura K. J Pharmacol Sci. 2011;117(3):129-38.

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Rapavi E, Kocsis I, Fehér E, Szentmihályi K, Lugasi A, Székely E, Blázovics A. Nat Prod Res. 2007 Mar;21(3):274-81.

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Pradeep K, Park SH, Ko KC. Eur J Pharmacol. 2008 Jun 10;587(1-3):273-80.

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Pradeep K, Ko KC, Choi MH, Kang JA, Chung YJ, Park SH. J Med Food. 2012 May;15(5):419-27.

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Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y, Kibata M. J Nutr Sci Vitaminol (Tokyo). 2005 Dec;51(6):460-70.

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Dandelion Root

[Dandelion] significantly increased activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) in liver and muscle protein. [Dandelion] significantly suppressed lipid accumulation in the liver, reduced [metabolic hormone] resistance, and lipid in HFD-fed C57BL/6 mice via the AMPK pathway.
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Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MJ, Kwon DY, Sung MJ. Food Chem Toxicol. 2013 Aug;58:30-6. doi: 10.1016/j.fct.2013.04.023. Epub 2013 Apr 18.

Davaatseren M, Hur HJ, Yang HJ, Hwang JT, Park JH, Kim HJ, Kim MS, Kim MJ, Kwon DY, Sung MJ. J Med Food. 2013 Jan;16(1):26-33. doi: 10.1089/jmf.2012.2226. Epub 2012 Dec 20.

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Hfaiedh M, Brahmi D, Zourgui L. Environ Toxicol. 2016 Mar;31(3):339-49. doi: 10.1002/tox.22048. Epub 2014 Oct 1.

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Domitrović R, Jakovac H, Romić Z, Rahelić D, Tadić Z. J Ethnopharmacol. 2010 Aug 9;130(3):569-77. doi: 10.1016/j.jep.2010.05.046. Epub 2010 Jun 2.

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Wirngo FE, Lambert MN, Jeppesen PB. Rev Diabet Stud. 2016 Summer-Fall; 13(2-3): 113–131.

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Choi UK, Lee OH, Yim JH, Cho CW, Rhee YK, Lim SI, Kim YC. Int J Mol Sci. 2010 Jan; 11(1): 67–78.

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Artichoke Leaf

Doppler sonography showed increased hepatic vein flow[...], reduced portal vein diameter [...], and liver size [...], reduction in serum ALT [...] and AST [...] levels, improvement in AST/ALT ratio and APRI scores [...], and reduction in total bilirubin. [Artichoke leaf] supplementation reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations.
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Panahi Y, Kianpour P, Mohtashami R, Atkin SL, Butler AE, Jafari R, Badeli R, Sahebkar A. Phytother Res. 2018 Jul;32(7):1382-1387. doi: 10.1002/ptr.6073. Epub 2018 Mar 9.

Tang X, Wei R, Deng A, Lei T. Nutrients. 2017 Sep; 9(9): 1000.

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Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A. Int J Hepatol. 2016; 2016: 4030476.

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Ahmadi A, Heidarian E, Ghatreh-Samani K. J Basic Clin Physiol Pharmacol. 2019 Aug 30;30(5). pii: /j/jbcpp.2019.30.issue-5/jbcpp-2018-0180/jbcpp-2018-0180.xml. doi: 10.1515/jbcpp-2018-0180.

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Kurt H, Toprak O, Bülbül E. Case Reports Hepatol. 2014; 2014: 697359.

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Choline Bitartrate

[Subjects] were divided into two groups and fed a [choline deficient] diet with or without 0.2% choline bitartrate for one or three weeks. [...] The [choline deficient] diet lowered liver choline metabolites after one week and exacerbated fatty liver between one and three weeks. We identified >300 genes whose expression was significantly altered in the livers of mice after consumption of this CD diet for one week.
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Mitsumoto K, Watanabe R, Nakao K, Yonenaka H, Hashimoto T, Kato N, Kumrungsee T, Yanaka N. Life Sci. 2017 Sep 1;184:103-111. doi: 10.1016/j.lfs.2017.07.009. Epub 2017 Jul 12.

Sherriff JL, O'Sullivan TA, Properzi C, Oddo JL, Adams LA. Adv Nutr. 2016 Jan; 7(1): 5–13.

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Corbin KD, Zeisel SH. Curr Opin Gastroenterol. 2012 Mar; 28(2): 159–165.

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Mehedint MG, Zeisel SH. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3): 339–345.

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Wiedeman AM, Barr SI, Green TJ, Xu Z, Innis SM, Kitts DD. Nutrients. 2018 Oct; 10(10): 1513.

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Schugar RC, Huang X, Moll AR, Brunt EM, Crawford PA. PLoS One. 2013; 8(8): e74806.

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Heo G, Suk K. Prev Nutr Food Sci. 2019 Mar; 24(1): 32–40.

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