Calciven Ingredient Research

Calcium

Calcium

"Calcium intake influences skeletal calcium retention during growth and thus affects peak bone mass achieved in early adulthood. Increased calcium intake is associated with increased bone mineral accretion rate up to a threshold level in all ethnic groups."

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Zhu K, Prince RL. Clin Biochem. 2012 Aug;45(12):936-42.

Sunyecz JA.

Ther Clin Risk Manag. 2008 Aug; 4(4): 827–836.

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Ye SK, Ren X, Meng XX, Chen HY.

Exp Ther Med. 2020 Feb;19(2):1432-1438.

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Shea B, Wells G, Cranney A, Zytaruk N, Robinson V, Griffith L, Hamel C, Ortiz Z, Peterson J, Adachi J, Tugwell P, Guyatt G

Cochrane Database Syst Rev. 2004;(1):CD004526.

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Malpeli A, Apezteguia M, Mansur JL, Armanini A, Macías Couret M, Villalobos R, Kuzminczuk M, Gonzalez HF.

Arch Latinoam Nutr. 2012 Mar;62(1):30-6. PMID: 23477205.

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Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD.

Osteoporos Int. 2016 Jan;27(1):367-76.

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Magnesium

Magnesium

"Significantly increased accrual [...] in integrated hip [bone mineral content] occurred in the [magnesium]-supplemented vs. placebo group. [...] Lumbar spinal [bone mineral content] accrual was slightly [...] greater in the Mg-treated group. [...] A positive effect of Mg supplementation on integrated hip [bone mineral content] was evident."

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Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D, Cohen D. CJ Clin Endocrinol Metab. 2006 Dec;91(12):4866-72.

Castiglioni S, Cazzaniga A, Albisetti W, Maier JA.

Nutrients. 2013 Jul 31;5(8):3022-33.

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Welch AA, Skinner J, Hickson M.

Nutrients. 2017 Oct 30;9(11):1189.

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Ryder KM, Shorr RI, Bush AJ, Kritchevsky SB, Harris T, Stone K, Cauley J, Tylavsky FA.

J Am Geriatr Soc. 2005 Nov;53(11):1875-80.

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Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D, Cohen D.

J Clin Endocrinol Metab. 2006 Dec;91(12):4866-72.

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Sojka JE, Weaver CM.

Nutr Rev. 1995 Mar;53(3):71-4.

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Rude RK, Olerich M.

Osteoporos Int. 1996;6(6):453-61.

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Boron

Boron

"The results suggest that boron supplementation improves parameters related to bone strength and microstructure of cortical and trabecular bone."

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Dessordi R, Spirlandeli AL, Zamarioli A, Volpon JB, Navarro AM. J Trace Elem Med Biol. 2017 Jan;39:169-175.

Meacham SL, Taper LJ, Volpe SL.

Environ Health Perspect. 1994 Nov;102 Suppl 7(Suppl 7):79-82.

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Rondanelli M, Faliva MA, Peroni G, Infantino V, Gasparri C, Iannello G, Perna S, Riva A, Petrangolini G, Tartara A.

J Trace Elem Med Biol. 2020 Dec;62:126577.

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Toker H, Ozdemir H, Balci Yuce H, Goze F.

J Dent Sci. 2016 Sep;11(3):331-337.

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Nielsen FH.

Magnes Trace Elem. 1990;9(2):61-9.

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Sheng MH, Taper LJ, Veit H, Thomas EA, Ritchey SJ, Lau KH.

Biol Trace Elem Res. 2001 Jul;81(1):29-45.

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Vitamin K2

Vitamin K2

"Vitamin K2 promotes arterial flexibility by preventing accumulation of arterial calcium, and supplementation with it could correct calcium amounts in the body that are out of balance. Thus, calcium in tandem with vitamin K2 may well be the solution for bringing necessary bone benefits."

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Maresz K. Integr Med (Encinitas). 2015 Feb;14(1):34-9.

Akbari S, Rasouli-Ghahroudi AA.

Biomed Res Int. 2018 Jun 27;2018:4629383.

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van Ballegooijen AJ, Pilz S, Tomaschitz A, Grübler MR, Verheyen N.

Int J Endocrinol. 2017;2017:7454376.

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Iwamoto J, Takeda T, Sato Y.

Curr Pharm Des. 2004;10(21):2557-76.

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Kodama Y, Okamoto Y, Kubota T, Hiroyama Y, Fukami H, Matsushita K, Kawano Y.

Brain Dev. 2017 Nov;39(10):846-850.

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Plaza SM, Lamson DW.

Altern Med Rev. 2005 Mar;10(1):24-35.

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Vitamin D3

Vitamin D3

"Meta-analysis of all studies showed that calcium plus vitamin D supplementation produced a statistically significant 15 % reduced risk of total fractures [...] and a 30 % reduced risk of hip fractures [...] This meta-analysis of RCTs supports the use of calcium plus vitamin D supplements as an intervention for fracture risk reduction."

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Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD. Osteoporos Int. 2016 Jan;27(1):367-76.

Sunyecz JA.

Ther Clin Risk Manag. 2008 Aug;4(4):827-36.

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Lips P, van Schoor NM.

Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91.

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Brincat M, Gambin J, Brincat M, Calleja-Agius J.

Maturitas. 2015 Mar;80(3):329-32.

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Sadat-Ali M, Al Elq AH, Al-Turki HA, Al-Mulhim FA, Al-Ali AK.

Ann Saudi Med. 2011 Nov-Dec;31(6):602-8.

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