I received my first bottle two weeks ago today and immediately took my first two pills. The pills went down easily with a drink. Some of the advertised benefits can be a bit subjective. I started feeling a bit more vitality really quickly -- nothing astounding, in fact, I wondered if I was feeling some kind of placebo effect and whether it would last. But as I continued taking it, I have been significantly calmer and less cranky without any effort on my part.